Key: Win : Draw : Loss
| Date | Home | Away | Ref | ||
|---|---|---|---|---|---|
| 07/08/2010 | Bury | 0 | 1 | Port Vale | R Madley |
| 14/08/2010 | Port Vale | 1 | 1 | Chesterfield | K Evans |
| 21/08/2010 | Southend | 1 | 3 | Port Vale | R East |
| 28/08/2010 | Port Vale | 1 | 2 | Torquay | G Eltringham |
| 04/09/2010 | Bradford | 0 | 2 | Port Vale | D Coote |
| 11/09/2010 | Port Vale | 1 | 0 | Aldershot | M Brown |
| 18/09/2010 | Macclesfield | 0 | 3 | Port Vale | M Oliver |
| 25/09/2010 | Port Vale | 2 | 0 | Accrington | T Kettle |
| 28/09/2010 | Port Vale | 1 | 0 | Shrewsbury | S Mathieson |
| 02/10/2010 | Oxford | 2 | 1 | Port Vale | G Ward |
| 09/10/2010 | Hereford | 1 | 1 | Port Vale | D McDermid |
| 16/10/2010 | Port Vale | 0 | 0 | Gillingham | C Boyeson |
| 23/10/2010 | Cheltenham | 0 | 0 | Port Vale | D Whitestone |
| 30/10/2010 | Port Vale | 2 | 1 | Crewe | A Taylor |
| 02/11/2010 | Burton | 0 | 0 | Port Vale | P Quinn |
| 13/11/2010 | Northampton | 0 | 0 | Port Vale | I Williamson |
| 20/11/2010 | Port Vale | 2 | 1 | Wycombe | J Moss |
| 23/11/2010 | Stockport | 0 | 5 | Port Vale | C Webster |
| 11/12/2010 | Morecambe | 1 | 0 | Port Vale | R Shoebridge |
| 28/12/2010 | Gillingham | 3 | 0 | Port Vale | F Graham |
| 01/01/2011 | Rotherham | 5 | 0 | Port Vale | G Salisbury |
| 03/01/2011 | Port Vale | 2 | 1 | Burton | M Naylor |
| 15/01/2011 | Crewe | 2 | 1 | Port Vale | S Tanner |
| 22/01/2011 | Port Vale | 0 | 1 | Cheltenham | P Tierney |
| 25/01/2011 | Port Vale | 0 | 0 | Barnet | D Webb |
| 29/01/2011 | Lincoln | 1 | 0 | Port Vale | A Woolmer |
| 01/02/2011 | Port Vale | 1 | 0 | Rotherham | K Evans |
| 05/02/2011 | Wycombe | 1 | 1 | Port Vale | G Sutton |
| 12/02/2011 | Port Vale | 1 | 1 | Northampton | B Malone |
| 18/02/2011 | Port Vale | 2 | 1 | Bradford | G Ward |
| 22/02/2011 | Port Vale | 1 | 3 | Stevenage | N Swarbrick |
| 26/02/2011 | Aldershot | 1 | 2 | Port Vale | I Williamson |
| 05/03/2011 | Port Vale | 2 | 1 | Macclesfield | A Haines |
| 08/03/2011 | Shrewsbury | 2 | 2 | Port Vale | P Gibbs |
| 12/03/2011 | Port Vale | 1 | 2 | Oxford | P Tierney |
| 19/03/2011 | Accrington | 3 | 0 | Port Vale | D Foster |
| 22/03/2011 | Port Vale | 1 | 1 | Hereford | D Deadman |
| 26/03/2011 | Port Vale | 0 | 0 | Bury | D Sheldrake |
| 29/03/2011 | Port Vale | 2 | 1 | Lincoln | R Booth |
| 02/04/2011 | Chesterfield | 2 | 0 | Port Vale | S Tanner |
| 09/04/2011 | Port Vale | 1 | 1 | Southend | P Gibbs |
| 16/04/2011 | Torquay | 0 | 0 | Port Vale | D Phillips |
| 23/04/2011 | Port Vale | 1 | 2 | Stockport | P Quinn |
| 25/04/2011 | Stevenage | 1 | 0 | Port Vale | J Waugh |
| 30/04/2011 | Port Vale | 7 | 2 | Morecambe | R Lewis |
| 07/05/2011 | Barnet | 1 | 0 | Port Vale | R East |